David A. Boothman
Associate Director of Translational Research
Indiana University
United States
Biography
Dr. Boothman grew up in Detroit, Michigan, and earned his B.S. at the University of Michigan-Ann Arbor. He did his graduate work in microbiology and immunology at the University of Miami Medical School, where he received his Ph.D. under the mentorship of Dr. Sheldon Greer. His research focused on the biochemistry and pharmacology of anticancer drugs, specifically 5-fluoro-deoxycytidine derivatives. He did postdoctoral research at the Dana-Farber Cancer Institute of Harvard Medical School with Dr. Arthur B. Pardee. There, he investigated changes in several aspects of cancer cells before and after cell stress: cell cycle checkpoint regulation, molecular biology, and gene expression. His studies on β-lapachone as a radiosensitizer and DNA repair inhibitor began at this time. Dr. Boothman also discovered and cloned the first proteins and transcripts induced by ionizing radiation (IR). Dr. Boothman has trained 16 Ph.D. students, two M.D./Ph.D. students, and more than 40 postdoctoral fellows and residents, who enjoy positions around the nation and in seven different countries and in various aspects of scientific research.
Research Interest
Cancer, Diabetes Endocrinology, Global Health, Infectious Diseases